Acoustical characterization of submicron particles of perfluorocarbon in solution [ultrasound targeted contrast agent]

Author

Couture, O. ; Cherin, E. ; Foster, F.S.

Author_Institution

Sunnybrook & Women´´s Coll. Health Sci. Centre, Toronto, Ont., Canada

Volume

2

fYear

2004

fDate

23-27 Aug. 2004

Firstpage

1387

Abstract

Determining the acoustical properties of submicron particles of perfluorocarbon in solution is important to explain their response to ultrasound pulses when bound to a target. In this study, we present measurements of the frequency-dependent attenuation at different particle sizes, pressures and bandwidths. Backscattering spectra of the particles probed with narrowband pulses at 33 MHz are also shown. This study demonstrates the linearity of submicron particles made of liquid perfluorocarbon at high frequency.

Keywords

backscatter; biomedical ultrasonics; frequency response; organic compounds; particle size; ultrasonic absorption; ultrasonic scattering; 33 MHz; backscattering spectra; frequency-dependent attenuation; high frequency response linearity; liquid perfluorocarbon; particle size; perfluorocarbon in solution; submicron particle acoustical characterization; submicron particles; target bound perfluorocarbon; tissue/blood contrast; ultrasound pulse response; ultrasound targeted contrast agent; Acoustic measurements; Acoustic pulses; Attenuation measurement; Backscatter; Bandwidth; Frequency measurement; Particle measurements; Size measurement; Ultrasonic imaging; Ultrasonic variables measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2004 IEEE

ISSN

1051-0117

Print_ISBN

0-7803-8412-1

Type

conf

DOI

10.1109/ULTSYM.2004.1418056

Filename

1418056