DocumentCode :
452771
Title :
Glucose Oxidase (GOD)-Coupled Amperometric Microsensor with Integrated Electrochemical Actuation System
Author :
Park, Jongwon ; Kim, Chang-Soo ; Zhang, Shanrui ; Choi, Minsu
Author_Institution :
Missouri Univ., Rolla, MO
Volume :
1
fYear :
2005
fDate :
16-19 May 2005
Firstpage :
134
Lastpage :
138
Abstract :
Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. In order to address this issue, a novel solid-state glucose oxidase-coupled amperometric biosensor with integrated electrochemical actuation system has been designed and validated. There are two key components of the proposed glucose biosensor: solid-state GOD-coupled thin-1m amperometric sensing element and O2 depleting/saturating built-in electrochemical actuator. The actuator can be used to accomplish in-situ 1-point self-calibration by depleting O2 (i.e., by simulating glucose-free environment). Also, it can be used at the same time to extend the proposed sensor\´s linear detection range by increasing O2 (i.e., by enhancing glucose sensitivity). A prototype sensor was fabricated and a series of lab experiments was conducted. Collected data assures that the proposed sensor effectively establishes the zero calibration point and significantly enhances its measurement sensitivity and confidence
Keywords :
amperometric sensors; biosensors; electrochemistry; microactuators; microsensors; oxygen; sugar; GOD; O2; amperometric sensing element; built-in electrochemical actuator; glucose oxidase-coupled amperometric microsensor; in-situ 1-point self-calibration; integrated electrochemical actuation system; oxygen depletion; oxygen saturation; solid-state glucose oxidase-coupled amperometric biosensor; Actuators; Amperometric sensors; Biosensors; Calibration; Electrodes; Microsensors; Prototypes; Solid state circuits; Sugar; Thin film sensors; Actuator; GOD(Glucose oxidase); Glucose measurement; Solid-state biosensor; thin-lm amperometric sensor;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Instrumentation and Measurement Technology Conference, 2005. IMTC 2005. Proceedings of the IEEE
Conference_Location :
Ottawa, Ont.
Print_ISBN :
0-7803-8879-8
Type :
conf
DOI :
10.1109/IMTC.2005.1604085
Filename :
1604085
Link To Document :
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