Highly multiplexed antibody-antigen detection using nanoscale optofluidic resonators

Author

Mandal, Sudeep ; Goddard, Julie ; Erickson, David

Author_Institution

Sch. of Appl. & Eng. Phys., Cornell Univ., Ithaca, NY, USA

fYear

2009

fDate

2-4 June 2009

Firstpage

1

Lastpage

2

Abstract

We demonstrate a highly multiplexable optofluidic biosensor consisting of arrays of evanescently coupled photonic crystal resonators. We show the ability to monitor binding kinetics of Anti-Streptavidin in real-time and investigate the limit-of-detection (LOD) of the sensor.

Keywords

biochemistry; biological techniques; biosensors; integrated optics; molecular biophysics; nanofluidics; nanophotonics; nanosensors; optical arrays; optical resonators; photonic crystals; proteins; anti-streptavidin; antibody-antigen detection; binding kinetics; evanescent coupling; limit-of-detection; multiplexable optofluidic biosensor; nanoscale optofluidic resonators; photonic crystal resonators; Biosensors; Kinetic theory; Monitoring; Optical resonators; Optical sensors; Optoelectronic and photonic sensors; Photonic crystals; Resonance; Sensor arrays; Sensor phenomena and characterization; (050.5298) Photonic crystals; (130.3120) Integrated optics devices; (230.7370) Waveguides; (280.4788) Optical sensing and sensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics, 2009 and 2009 Conference on Quantum electronics and Laser Science Conference. CLEO/QELS 2009. Conference on

Conference_Location

Baltimore, MD

Print_ISBN

978-1-55752-869-8

Electronic_ISBN

978-1-55752-869-8

Type

conf

Filename

5225474