Statistical Study on Disease-Related ncRNAs Using Z-curve Method

It has become very important to study non-coding RNAs in the recent years. The Z curve is a very useful method for visualizing and analyzing DNA sequences among the approaches of researching ncRNAs. It is a three-dimensional space curve that constitutes a unique representation of a given DNA sequence, i.e., both the Z-curve and the given DNA sequence can be uniquely reconstructed from the other. Using Z curve method, we select 15 disease related ncRNAs sequences from the NONCODE database, which relate with Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are obtained. These features indicate that the ncRNAs sequences, which play same roles in the cellular process, have almost the same Z-curves. And the base content in these sequences is almost same too, in spite of coming from different organisms.