Title :
pH-triggered release of paclitaxel from nanoengineered polymeric capsules
Author :
Pastorino, Laura ; Soumetz, Federico Caneva ; Ruggiero, Carmelina ; Erokhina, Svetlana
Author_Institution :
Dept. of Commun., Comput. & Syst., Sci., Univ. of Genova, Genova, Italy
Abstract :
Paclitaxel is an anticancer agent often used in clinical oncology practice. Polymeric capsules represent an effective tool for the encapsulation and smart release of different compounds. Paclitaxel was loaded into the capsules, fabricated by means of the layer-by-layer assembly of oppositely charged polyelectrolytes. The effective encapsulation of paclitaxel was demonstrated and its release was characterized. Finally the biological activity of encapsulated paclitaxel against human breast cancer cells was assessed.
Keywords :
biochemistry; biological organs; cancer; cellular biophysics; drugs; encapsulation; gynaecology; nanobiotechnology; nanostructured materials; pH; patient treatment; polymer electrolytes; self-assembly; anticancer agent; biological activity; breast cancer cells; chemotherapy; encapsulation; layer-by-layer assembly; nanoengineered polymeric capsules; paclitaxel pH-triggered release; polyelectrolytes; Breast cancer; Cells (biology); Drug delivery; Encapsulation; Fabrication; Humans; Medical treatment; Nanobioscience; Oncology; Polymers; cytotoxicity; paclitaxel; polyelectrolyte self-assembling; polymeric capsules; triggered release;
Conference_Titel :
Nanotechnology, 2009. IEEE-NANO 2009. 9th IEEE Conference on
Conference_Location :
Genoa
Print_ISBN :
978-1-4244-4832-6
Electronic_ISBN :
1944-9399
