Design and implementation of integrated front-end readout circuit for linear-array biosensors with chopper-stabilized operational amplifier

Author

Sun, Tai-Ping ; Shieh, Hsiu-Li ; Tang, Yi-Ching ; Tsai, Chun-Lang ; Huang, Hsin-Wei ; Liu, Wei-Hao ; Liu, Chia-Ming ; Chang, Jen-Wei ; Li, Jia-Hao ; Ching, Congo Tak-Shing

Author_Institution

Grad. Inst. of Biomedicine & Biomed. Technol., Nat. Chi Nan Univ., Nantou Hsien, Taiwan

Volume

4

fYear

2010

fDate

16-18 Oct. 2010

Firstpage

1447

Lastpage

1449

Abstract

A readout circuit for the linear array pH sensor was designed and developed, using chopper stabilization technique. It consisted of analog multiplexer, chopper stabilized operational amplifier, level shift, filter and buffer stage. The operational amplifier used in this design was a folded cascade amplifier. Results showed that the circuit can reduce input offset, drift voltage and noise. Moreover, noise can be further reduced on a faster chopper frequency. This readout circuit can be used for measuring small signal of low frequency biosensor. The readout circuit design was implemented using TSMC 0.35um 2P4M standard CMOS process.

Keywords

CMOS analogue integrated circuits; biosensors; chemical sensors; choppers (circuits); network synthesis; noise; operational amplifiers; pH measurement; CMOS; buffer stage; chopper-stabilized operational amplifier; drift voltage; faster chopper frequency; filter stage; folded cascade amplifier; integrated front-end readout circuit; linear array pH sensor; linear-array biosensors; low frequency biosensor; noise; readout circuit design; Arrays; Biosensors; Choppers; Electrodes; Operational amplifiers; Signal to noise ratio; Array; Biosensors; Chopper-Stabilized Operational Amplifier; Readout Circuit;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on

Conference_Location

Yantai

Print_ISBN

978-1-4244-6495-1

Type

conf

DOI

10.1109/BMEI.2010.5639393

Filename

5639393