Investigation and evaluation of optimal registration for medical CT images

Due to its capability of maximizing the embedded information from a large amount of medical images captured from different imaging modalities and acquired from different scanning intervals, medical image registration plays an essential role in clinical applications including diagnosis, radiotherapy planning, assessment of patient´s response to the treatment. An intensive research on registration methodologies has been conducted during the last three decades. However, by far there is no general software solution to clinically acceptable registration. To sort out more appropriate registration for clinical CT images, in this paper, the-state-of-the-art registration methods were tested and compared. In particular, the multiresolution deformable registration was investigated for accommodating a wider range of deformations. Our experimental results on the clinical CT datasets demonstrated the superior performance of the B-spline deformable registration by multiresolution scheme.