Title :
Active analog approach to Histamine HI receptor antagonists
Author :
Ritter, A. ; Gerula, Christine M. ; Yadav, J.
Author_Institution :
Dept. of Physiol., Univ. of Med. & Dentistry of NJ, Newark, NJ, USA
fDate :
Oct. 29 1992-Nov. 1 1992
Abstract :
Molecular modeling studies have been carried out to compare static, electronic and electrostatic properties of some Histamine H1 receptor antagonists using SYBYL package. The present work does suggest a correlation between structure function relationships of these molecules.
Keywords :
biochemistry; bioelectric phenomena; biology computing; drugs; electrostatics; molecular biophysics; physiological models; proteins; SYBYL package; active analog approach; electronic properties; electrostatic properties; histamine H1 receptor antagonists; molecular modeling; static properties; structure function relationships; Computational modeling; Electrostatics; Periodic structures;
Conference_Titel :
Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE
Conference_Location :
Paris
Print_ISBN :
0-7803-0785-2
Electronic_ISBN :
0-7803-0816-6
DOI :
10.1109/IEMBS.1992.5760929
