Title :
A physiologic-based circuit model of the postsynaptic region at the neuromuscular junction
Author :
Levine, Michael D. ; Eisenberg, Marvin F. ; Fare, Thomas L.
Author_Institution :
Dept. of Electr. Eng./Comput. Sci., George Washington Univ., Washington, DC, USA
fDate :
Oct. 29 1992-Nov. 1 1992
Abstract :
A metal-oxide-semiconductor field-effect transistor (MOSFET) is used as the circuit analog to simulate a group of excitatory transmitter-gated ion channels. This analog is incorporated into a circuit model of the postsynaptic membrane at the neuromuscular junction. Simulation of the model yields an output representing the overall membrane potential of the postsynaptic region. Simulation is performed for the normal and pathologic (myasthenia gravis) states.
Keywords :
MOSFET circuits; biomedical electronics; biomembranes; neuromuscular stimulation; physiology; MOSFET; circuit analog; excitatory transmitter-gated ion channels; metal-oxide-semiconductor field-effect transistor; myasthenia gravis states; neuromuscular junction; physiologic-based circuit model; postsynaptic membrane potential; Extracellular;
Conference_Titel :
Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE
Conference_Location :
Paris
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1992.5761944
