DocumentCode
545920
Title
Notice of Retraction
Effect of DEHP on Learning and Memory Ability of Kunming Mice
Author
Jiaqi Tang ; Ye Yuan ; Jing Guo ; Xiaomei Liao ; Xu Yang
Author_Institution
Hubei Key Lab. of Genetic Regul. & Integrative Biol., Central China Normal Univ., Wuhan, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Di (2-ethylhexyl) phthalate (DEHP) was used in the plastic industry and widely distributed in the environment, which might cause adverse effects to living organisms. To study the effects of DEHP on learning and memory, the KM mice were exposed to different concentrations of DEHP (0, 5, 50 and 500 mg/kg·d) for fourteen days. With the exposed, the Morris water maze was used to test the learning abilities of mice in the 1st to the 10th day, and the memory by probe trial test in the 14th day. Then the reactive oxygen species (ROS) and malondialdehyde (MDA) content of brains were measured. The results showed that with the increase of DEHP concentrations, increasing of ROS and MDA contents were observed, and the learning abilities and memory were reduced. These results suggested that DEHP could induce the acute oxidative damage in brains of mice, and have negative effects on the learning abilities and memory.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Di (2-ethylhexyl) phthalate (DEHP) was used in the plastic industry and widely distributed in the environment, which might cause adverse effects to living organisms. To study the effects of DEHP on learning and memory, the KM mice were exposed to different concentrations of DEHP (0, 5, 50 and 500 mg/kg·d) for fourteen days. With the exposed, the Morris water maze was used to test the learning abilities of mice in the 1st to the 10th day, and the memory by probe trial test in the 14th day. Then the reactive oxygen species (ROS) and malondialdehyde (MDA) content of brains were measured. The results showed that with the increase of DEHP concentrations, increasing of ROS and MDA contents were observed, and the learning abilities and memory were reduced. These results suggested that DEHP could induce the acute oxidative damage in brains of mice, and have negative effects on the learning abilities and memory.
Keywords
biotechnology; brain; plastics industry; Kunming mice learning ability; Kunming mice memory ability; living organisms; malondialdehyde content; mice brains; plastic industry; reactive oxygen species; Chemicals; Humans; Laboratories; Mice; Pediatrics; Stress;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5781374
Filename
5781374
Link To Document