The effect of cell shape on local hydrodynamic environment

Author

Fu, Yi ; Fang, Ying ; Wu, Jianhua ; Dong, Cheng

Author_Institution

Sch. of Biosci. & Bioeng., South China Univ. of Technol., Guangzhou, China

Volume

1

fYear

2011

fDate

9-11 Dec. 2011

Firstpage

540

Lastpage

543

Abstract

Cell adhesion is very important for various biological phenomena in blood flow. Cells would deform to resist the hydrodynamic forces on the blood vessel wall, which results in local flow environment change due to the disturbance of adherent cells. In this paper, computational fluid dynamics simulations were performed to investigate the effect of cell shape on local hydrodynamic environment in details. We found that under a flow condition 73 μl/min, cell shape would more affect the flow in one cell height region. Moreover, cell length, the position of cell top and cell shape curvature may also affect the local hydrodynamic environment as well as the drag forces differently.

Keywords

adhesion; blood vessels; cellular biophysics; computational fluid dynamics; drag; haemodynamics; haemorheology; hydrodynamics; adherent cell disturbance; biological phenomena; blood flow; blood vessel wall; cell adhesion; cell height; cell length; cell shape effect; computational fluid dynamics simulations; drag forces; hydrodynamic forces; local flow environment; local hydrodynamic environment; Adhesives; Computational fluid dynamics; Deformable models; Drag; Hydrodynamics; Mathematical model; Shape; cell adhesion; cell shape; computational fluid dynamics; local hydrodynamic environment; side-view μPIV;

fLanguage

English

Publisher

ieee

Conference_Titel

IT in Medicine and Education (ITME), 2011 International Symposium on

Conference_Location

Cuangzhou

Print_ISBN

978-1-61284-701-6

Type

conf

DOI

10.1109/ITiME.2011.6130895

Filename

6130895