DocumentCode :
57226
Title :
Label-Free 
Photonic Crystal Based Immunosensors for Diagnostic Applications
Author :
Zecca, D. ; Qualtieri, A. ; Magno, G. ; Grande, M. ; Petruzzelli, V. ; Prieto-Simon, B. ; D´Orazio, A. ; De Vittorio, M. ; Voelcker, N.H. ; Stomeo, T.
Author_Institution :
Center for Bio-Mol. Nanotechnol., Ist. Italiano di Tecnol. (IIT), Lecce, Italy
Volume :
6
Issue :
6
fYear :
2014
fDate :
Dec. 2014
Firstpage :
1
Lastpage :
7
Abstract :
Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm × 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.
Keywords :
biochemistry; biomedical equipment; cancer; chemical sensors; membranes; molecular biophysics; nanofabrication; nanomedicine; nanosensors; patient diagnosis; photonic crystals; proteins; silicon compounds; 2-D photonic crystal silicon nitride membrane; Si3N4; cancer; cardiac dysfunctions; diagnostic applications; diseases; high-quality photonic pattern; immobilized antibodies; interleukin-6 detection; label-free Si3N4 photonic crystal based immunosensors; nanofabrication; protein detection; Biosensors; Medical diagnosis; Optical sensors; Photonic crystals; Silicon; Photonic crystals (PhC); biosensors; fabrication and characterization;
fLanguage :
English
Journal_Title :
Photonics Journal, IEEE
Publisher :
ieee
ISSN :
1943-0655
Type :
jour
DOI :
10.1109/JPHOT.2014.2352625
Filename :
6892930
Link To Document :
