Clinical evaluation of DoctorEye platform in nephroblastoma

Nephroblastoma is the most common malignant renal tumor in children. Today about 90 % of the patients can be cured by chemotherapy and surgery. Most of the patients are enrolled in prospective clinical trials. In the SIOP (International Society of Pediatric Oncology) approach all children do receive preoperative chemotherapy to shrink the tumor before surgery. Patients with an excellent response to preoperative chemotherapy have a better outcome than those with a poor response. Response is not only defined by tumor volume shrinkage but also by the vanishing of blastemal tumor cells. Imaging studies are used to calculate tumor volume and to define vital, necrotic and cystic areas within a tumor. In case of nephroblastoma it would be of most importance to further separate the vital tumor in blastemal and non-blastemal components. This would allow changing treatment at an early phase in case of remaining blastema. Using the DoctorEye software, tumors can be easily rendered and histograms of the signal intensities within a tumor are possible to calculate. Our preliminary results show that these histograms give further insight in the tumors in single patients by correlating them with the histological findings.