Title :
Assessment for possible drug application delays in MCT strategy due to pathophysiological constraints of cancer
Author_Institution :
Dept. of Physiol., West Bengal State Univ., Kolkata, India
fDate :
Oct. 30 2012-Nov. 2 2012
Abstract :
Different analytical modelling showed that metronomic chemotherapeutic (MCT) strategy is a better option than maximum tolerable dosing (MTD) for the treatment of cancer under the condition of malignancy. In this work, a major physiological constraint, drug clearance rate has been considered. Incorporating it into analytical state-space models, the transformation of the overall system has been examined through computer simulations. Accumulation of drug, dead tumor cells and metabolites produced by living tumor cells in turn affect the subsequent drug application and thereby the therapeutic procedure and its outcome. Simulation results suggest that subsequent drug administration delay increases gradually with time due to this constraint.
Keywords :
cancer; cellular biophysics; delays; drug delivery systems; drugs; medical computing; tumours; analytical modelling; analytical state-space models; cancer treatment; computer simulations; dead tumor cells; drug application delays assessment; drug clearance rate; living tumor cells; malignancy; maximum tolerable dosing; metabolites; metronomic chemotherapeutic strategy; pathophysiological Constraints; subsequent drug application; therapeutic procedure; Communications technology; Decision support systems; Discrete wavelet transforms; MCT; MTD; cancer; drug clearance;
Conference_Titel :
Information and Communication Technologies (WICT), 2012 World Congress on
Conference_Location :
Trivandrum
Print_ISBN :
978-1-4673-4806-5
DOI :
10.1109/WICT.2012.6409122