Splicing of the triplet periodicity in genes from different species

Author

Suvorova, Yulia M. ; Korotkov, Eugene V.

Author_Institution

Bioinf. Lab., Centre of Bioeng., Moscow, Russia

fYear

2011

fDate

2-5 May 2011

Firstpage

124

Lastpage

128

Abstract

We found genes which contain more than one type of the triplet periodicity (TP) during their sequences. We say that these genes contain the triplet periodicity splicing (TPS). The aim of the work is to study such genes and try to understand the nature of the (TPS) phenomenon. The mathematical algorithm for detection of TP splicing of nucleotide sequences has been developed. Gene sequences from KEGG-48 databank were analyzed with a purpose of searching for genes with a TPS. The presence of a triplet periodicity splicing has been shown for 311221 genes (~8% from the total number of genes in KEGG-48). We showed that the repetitive or low-complexity sequences are not cause of the TPS. We suppose that the TPS cases may indicate fusion of genes or domains with different types of TP. The relationship between TPS and the fusion events in genes is discussed.

Keywords

DNA; biology computing; genetics; genomics; mathematical analysis; molecular biophysics; molecular configurations; KEGG-48 databank; gene fusion; gene sequences; low-complexity sequences; mathematical algorithm; nucleotide sequences; triplet periodicity splicing; Amino acids; Bioinformatics; DNA; Genomics; Proteins; Radio frequency; Splicing;

fLanguage

English

Publisher

ieee

Conference_Titel

Health Informatics and Bioinformatics (HIBIT), 2011 6th International Symposium on

Conference_Location

Izmir

Print_ISBN

978-2-4673-4394-4

Type

conf

DOI

10.1109/HIBIT.2011.6450821

Filename

6450821