Pathway curation: Application of text-mining tools eGIFT and RLIMS-P

Gallus Reactome provides a manually curated reference database for chicken signaling and metabolic pathways. Providing such a high-quality reference database requires significant time input from both curators and pathway experts. This paper describes the application of orthology prediction, computational linguistic tools including text mining and information extraction applications, along with resources available from the Protein Information Resource, to facilitate pathway curation. In this paper, we describe these methods in the context of curating the chicken TGF beta signaling pathway.