Preparation of spherical macroporous poly(lactic-co-glycolic acid) for bone tissue regeneration

Author

Chunhui Bian ; Huiming Lin ; Xiaofeng Li ; Jie Ma ; Pingping Jiang ; Fengyu Qu

Author_Institution

Dept. of Photoelectric Band Gap Mater., Harbin Normal Univ., Harbin, China

Volume

9

Issue

1

fYear

2015

fDate

2 2015

Firstpage

1

Lastpage

4

Abstract

Spherical macroporous poly(lactic-co-glycolic acid) (PLGA) has been synthesised using an emulsion method. Polyvinyl alcohol and Pluronic F127 have been used as dispersing and porogen agent, respectively. The diameter of the spherical PLGA is about 20 μm and the pore size of the PLGA macroporous is about 2-2.5 μm observed by scanning electron microscopy. After immersing in simulated body fluid, the PLGA materials can induce the formation of hydroxyapatite (HAP) on their surface. The HAP-PLGA has been obtained and used as the host for drug release. Furthermore, the drug-loaded samples possess the various drug release performance by adjusting the thickness of the HAP layer. This highly satisfied composite material is expected to be promising in the applications in tissue regeneration engineering.

Keywords

bioceramics; bone; calcium compounds; drug delivery systems; emulsions; materials preparation; polymer blends; porous materials; scanning electron microscopy; tissue engineering; Ca₁₀(PO₄)₆(OH)₂; HAP-PLGA; Pluronic F127 porogen agent; bone tissue regeneration; composite material; drug release; emulsion method; hydroxyapatite; polyvinyl alcohol dispersing agent; scanning electron microscopy; simulated body fluid; spherical macroporous poly(lactic-co-glycolic acid); tissue regeneration engineering;

fLanguage

English

Journal_Title

Nanobiotechnology, IET

Publisher

iet

ISSN

1751-8741

Type

jour

DOI

10.1049/iet-nbt.2013.0066

Filename

7036222