Separation of Ferucarbotran: A leading candidate of MPI tracer for practical use

Author

Nohara, S. ; Kato, Ippei ; Ito, Yu ; Honma, T. ; Ishihara, Yoshiyuki

Author_Institution

Meito Sangyo Co., Ltd., Japan

fYear

2013

fDate

23-24 March 2013

Firstpage

1

Lastpage

1

Abstract

It is well known that the possibility of use of Resovist® as a tracer for MPI has been studied, but whose performance using a practicable MPI device is not adequate. In this situation, it has been suggested that the fractionation of Resovist® shows good performance than Resovist® itself1,2,3). Meito Sangyo has been manufacturing Ferucarbotran, an active pharmaceutical ingredients (API) for Resovist®, since 2001, and are studying to obtain a practicable MPI tracer by separation of Ferucarbotran. Here, we report the physical properties such as MPI signal, particle size, T2 relaxivity and the biological behavior of the fractions from Ferucarbotran.

Keywords

biomedical materials; biomedical measurement; magnetic particles; nanomedicine; nanoparticles; pharmaceuticals; MPI signal; MPI tracer; Resovist fractionation; T2 relaxivity; active pharmaceutical ingredients; biological behavior; ferucarbotran separation; particle size; practical MPI device; Blood; Imaging; Kinetic theory; Magnetic cores; Magnetic separation; Performance evaluation;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetic Particle Imaging (IWMPI), 2013 International Workshop on

Conference_Location

Berkeley, CA

Print_ISBN

978-1-4673-5520-9

Electronic_ISBN

978-1-4673-5521-6

Type

conf

DOI

10.1109/IWMPI.2013.6528339

Filename

6528339