Title :
Singel molecule fluorescence spectroscopy couples with cell imaging and solid state NMR to reveal the earliest events in Alzheimer´s disease
Author_Institution :
Tata Inst. of Fundamental Res., Mumbai, India
Abstract :
The earliest detectable transformation in Alzheimer´s is the transition from monomers to oligomers of amyloid beta. We have discovered an aggregation related structural transition that seems to strongly alter the bio-acitivityof this species.
Keywords :
aggregation; biological NMR; cellular biophysics; diseases; fluorescence; solid-state phase transformations; Alzheimer disease; aggregation; amyloid beta; bioacitivity; cell imaging; monomers; oligomers; singel molecule fluorescence spectroscopy; state NMR; structural transition;
Conference_Titel :
Fiber Optics and Photonics (PHOTONICS), 2012 International Conference on
Conference_Location :
Chennai
Print_ISBN :
978-1-4673-4718-1
