Title :
Giga-pixel imaging on a chip: High numerical aperture lensfree microscopy over a wide field-of-view
Author :
Wei Luo ; Greenbaum, A. ; Ozcan, Aydogan
Author_Institution :
Electr. Eng. Dept., Univ. of California, Los Angeles, Los Angeles, CA, USA
Abstract :
We report an on-chip lensfree holographic microscope with a large field-of-view (FOV) of ~20.5 mm2 and a high numerical aperture (NA) of ~0.9. By implementing a pixel super-resolution technique on a color CMOS image sensor, this computational microscope achieves a spatial resolution of ~300 nm at an illumination wavelength of 530 nm, yielding approximately one billion useful pixels in both the reconstructed amplitude and phase images. This lensfree holographic on-chip imaging technique can be used as the building block for high resolution, compact and cost-effective optical microscopes for various biomedical imaging applications.
Keywords :
CMOS image sensors; biomedical optical imaging; holography; image colour analysis; image reconstruction; image resolution; medical image processing; optical microscopy; biomedical imaging applications; color CMOS image sensor; computational microscopy; giga-pixel imaging; high numerical aperture lensfree microscopy; illumination wavelength; lensfree holographic on-chip imaging technique; on-chip lensfree holographic microscopy; optical microscopy; phase image; pixel superresolution technique; reconstructed amplitude; spatial resolution; wavelength 530 nm; Image sensors; Microscopy; Optical microscopy; Sensors; Spatial resolution; giga-pixel microscopy; holographic microscopy; in-line holography; lensfree imaging; on-chip imaging; pixel super-resolution;
Conference_Titel :
Biomedical Imaging (ISBI), 2013 IEEE 10th International Symposium on
Conference_Location :
San Francisco, CA
Print_ISBN :
978-1-4673-6456-0
DOI :
10.1109/ISBI.2013.6556544
