Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured From a Human Prostate Tumor

Author

Hirst, Adam M. ; Frame, Fiona M. ; Maitland, Norman J. ; O´Connell, Dan

Author_Institution

Dept. of Phys. & Biol., Univ. of York, York, UK

Volume

42

Issue

10

fYear

2014

fDate

Oct. 2014

Firstpage

2740

Lastpage

2741

Abstract

Research in the new field of plasma medicine continues to demonstrate the efficacy of low temperature plasmas (LTPs) for numerous biomedical applications. Responses such as reduction in cell viability and cell death for cancer therapy, cell proliferation for wound healing, and bacterial inactivation have been observed as a result of plasma treatment. In this paper, we applied LTP to prostate cancer primary cells derived from patient tumour tissue to inflict irreparable DNA damage.

Keywords

DNA; cancer; cellular biophysics; microorganisms; molecular biophysics; plasma applications; radiation therapy; tumours; wounds; LTP; bacterial inactivation; biomedical applications; cancer therapy; cell death; cell proliferation; cell viability; double-strand break DNA damage; human prostate tumor; irreparable DNA damage; low-temperature plasma; patient tumour tissue; plasma medicine; plasma treatment; primary epithelial cells; prostate cancer primary cells; wound healing; Cancer; Cells (biology); DNA; Plasma temperature; Principal component analysis; Tumors; Atmospheric pressure plasma; DNA; cells (biology); oncology;

fLanguage

English

Journal_Title

Plasma Science, IEEE Transactions on

Publisher

ieee

ISSN

0093-3813

Type

jour

DOI

10.1109/TPS.2014.2351453

Filename

6894576