DocumentCode :
627857
Title :
Reduced Adhesion of Staphylococcus aureus to ZnO/PVC Nanocomposites
Author :
Geilich, Benjamin M. ; Webster, Thomas J.
Author_Institution :
Dept. of Chem. Eng., Northeastern Univ., Boston, MA, USA
fYear :
2013
fDate :
5-7 April 2013
Firstpage :
7
Lastpage :
8
Abstract :
In hospitals and clinics worldwide, medical device surfaces have become a rapidly growing source of nosocomial infections. In particular, patients requiring mechanical ventilation (and, thus, intubation with an endotracheal tube) for extended lengths of time are faced with a high probability of contracting ventilator-associated pneumonia. In this study, polyvinyl chloride (PVC) taken from a conventional endotracheal tube was embedded with varying concentrations of zinc oxide (ZnO) nanoparticles. Staphylococcus aureus biofilms were then grown on these nanocomposite surfaces during a 24-hour culture. Bacterial proliferation on the samples embedded with the highest concentration of ZnO nanoparticles was 87% less when compared to the control, indicating that this technique is effective at reducing biofilm formation on PVC surfaces without the use of antibiotics.
Keywords :
II-VI semiconductors; adhesion; antibacterial activity; biochemistry; biomedical equipment; cellular biophysics; filled polymers; materials preparation; microorganisms; nanocomposites; nanofabrication; nanomedicine; nanoparticles; particle reinforced composites; sterilisation (microbiological); wide band gap semiconductors; zinc compounds; Staphylococcus aureus adhesion reduction; Staphylococcus aureus biofilm formation; ZnO; bacterial proliferation; clinic; contracting ventilator-associated pneumonia; endotracheal tube; hospital; intubation; mechanical ventilation; medical device surface; nanocomposite surface; nosocomial infection; polyvinyl chloride; time 24 hour; zinc oxide nanoparticle; zinc oxide-PVC nanocomposite; Biomedical engineering; Staphylococcus aureus; biofilm; endotracheal tube; nanomaterials; nanoparticles; zinc oxide;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioengineering Conference (NEBEC), 2013 39th Annual Northeast
Conference_Location :
Syracuse, NY
ISSN :
2160-7001
Print_ISBN :
978-1-4673-4928-4
Type :
conf
DOI :
10.1109/NEBEC.2013.132
Filename :
6574330
Link To Document :
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