Delivery of Anti-Cancer Drugs Using Nanocarriers

Author

Lally, Beth ; Gettens, R. ; Sani, Shabnam

Author_Institution

Dept. of Biomed. Eng., Western New England Univ., Springfield, MA, USA

fYear

2013

fDate

5-7 April 2013

Firstpage

261

Lastpage

262

Abstract

The most prevalent form of cancer treatment used today is chemotherapy, although it is widely known to be associated with frequent, high dosages and unwanted side effects. The application of nanocarriers to conventional cancer treatment aims to address these problems by encapsulating chemotherapeutic drugs within polymer or lipid nanoparticles. These drug delivery nanoparticles, known as nanocarriers, work to increase the stability and circulation time of drugs and can be used to target specific areas. This project aims to fabricate nanocarriers for the delivery of chemotherapeutic drugs in order to address the current problems of chemotherapy. These nanocarriers will reduce side effects and issues of conventional dosage forms by targeting tumor sites, releasing drug specifically and only where it is needed.

Keywords

biomedical materials; cancer; dosimetry; drug delivery systems; drugs; encapsulation; lipid bilayers; nanofabrication; nanomedicine; nanoparticles; polymers; tumours; anticancer drug delivery; chemotherapeutic drug encapsulation; conventional cancer treatment; conventional dosage forms; drug circulation time; drug delivery nanoparticles; drug stability; lipid nanoparticles; nanocarriers; polymer nanoparticles; tumor sites; Cancer; Chemotherapy; Drug delivery; Drugs; Fabrication; Materials; Safety; PEG-PE; PLGA; emulsification-diffusion; lipid film hydration; nanocarriers; passive targeting;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2013 39th Annual Northeast

Conference_Location

Syracuse, NY

ISSN

2160-7001

Print_ISBN

978-1-4673-4928-4

Type

conf

DOI

10.1109/NEBEC.2013.74

Filename

6574458