Development and Study of a Hybrid Tissue Scaffold Fabrication System for Neurotrophin Delivery

Author

Jani, V.P. ; Patel, Rahul ; Reddy, R.K. ; Zhang, L.R. ; Wagner, C.T. ; Yan, C.K.

Author_Institution

Dept. of Biomed. Eng., Coll. of New Jersey, Ewing, NJ, USA

fYear

2013

fDate

5-7 April 2013

Firstpage

271

Lastpage

272

Abstract

Drug delivery to a biological system within the body requires precise control. Hybrid tissue scaffolds, manufactured via electrospinning, may be used in effective treatment of peripheral nerve damage. This study describes the development of such a scaffold, its characterization, and in vitro effectiveness; including the creation of an electrospinning apparatus capable of creating the tissue scaffold via coaxial spinning of biomaterials, material selection and testing, as well as mathematical modeling of the drug delivery profile.

Keywords

biological tissues; biomedical materials; drug delivery systems; drugs; electrospinning; injuries; mathematical analysis; molecular biophysics; neurophysiology; proteins; tissue engineering; biological system; biomaterials; coaxial spinning; drug delivery profile; electrospinning apparatus; hybrid tissue scaffold fabrication system; material selection; material testing; mathematical modeling; neurotrophin delivery; peripheral nerve damage; Drugs; Mathematical model; Polymers; Proteins; Testing; Tissue engineering; NGF; PC-12; coaxial electrospinning; controlled release; drug delivery; electrospinning; mathematical modeling; neural engineering; tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2013 39th Annual Northeast

Conference_Location

Syracuse, NY

ISSN

2160-7001

Print_ISBN

978-1-4673-4928-4

Type

conf

DOI

10.1109/NEBEC.2013.79

Filename

6574463