Synthesis of hierarchical porous bioactive glasses for bone tissue regeneration

A novel hierarchical porous bioactive glasses were synthesised with cattail stem and triblock polyethylene oxide-propylene oxide block copolymer (P123) as macroporous template and mesoporous template, respectively. The structural and textural properties of materials were characterised by X-ray diffraction, scanning electron microscope, Fourier transform infrared spectroscopy, nitrogen adsorption-desorption, energy dispersive spectrometer and vibrating sample magnetometer technique. The results reveal the bioglasses possess multilevel porous structure with the macroporous size about 50 μm and the mesopore with the diameter of 3.86 nm. Furthermore, metformin HCl was used as the model drug. The drug release kinetics and hydroxyapatite (HAP, (Ca₁₀(PO₄)₆(OH)₂)) inducing-growth ability of the composites were studied, respectively. The system exhibits the fast HAP inducing-growth ability and long-term drug delivery, making them a good candidate for bone tissue regeneration.