Compact silicon biosensor for the clinical range estimation of blood serum triglycéride

Author

Veeramani, M.S. ; Ratchagar, N.P. ; Bhattacharya, E. ; Pavan, Shanthi ; Prakash, Sachin ; Chadha, Anupama

Author_Institution

Dept. of Electr. Eng., Indian Inst. of Technol. Madras, Chennai, India

fYear

2013

fDate

3-6 Nov. 2013

Firstpage

1

Lastpage

4

Abstract

Electrolyte Insulator Semiconductor Capacitor (El S CAP) is a transducer that can detect triglycerides (TGs) in blood serum through an enzymatic response that changes the pH of the electrolyte (blood serum). This change in pH is transformed by the EISCAP to a shift in the capacitance-voltage (C-V) characteristics of the device which in turn can be mapped to the amount of TG in blood serum. We have developed a miniaturized biochip with immobilized enzyme integrated with a thin film counter electrode for the estimation of TG in blood serum within the clinical range. The miniaturized devices are tested using blood serum sample to estimate the TG concentration and compared with clinical data.

Keywords

bioelectric phenomena; biomedical electrodes; biomedical transducers; biosensors; blood; electrolytes; electrolytic capacitors; enzymes; lab-on-a-chip; molecular biophysics; pH; silicon; Si; blood serum triglyceride detection; capacitance-voltage characteristics; clinical data; clinical range estimation; compact silicon biosensor; electrolyte insulator semiconductor capacitor; immobilized enzyme; miniaturized biochip; pH; thin film counter electrode; transducer; Biochemistry; Biosensors; Blood; Electrodes; Sensitivity; Silicon;

fLanguage

English

Publisher

ieee

Conference_Titel

SENSORS, 2013 IEEE

Conference_Location

Baltimore, MD

ISSN

1930-0395

Type

conf

DOI

10.1109/ICSENS.2013.6688212

Filename

6688212