Palmtop waveguide-mode sensor: Comparison of sensitivity and subtyping of influenza viruses with SPR, ELISA and Immunochromatography

Author

Awazu, Koichi ; Fujimaki, Makoto ; Gopinath, Subash C. B.

Author_Institution

Electron. & Photonics Res. Inst., Nat. Inst. of Adv. Ind. Sci. & Technol. (NIST), Tsukuba, Japan

fYear

2013

fDate

3-6 Nov. 2013

Firstpage

1

Lastpage

3

Abstract

We developed a highly sensitive waveguide-mode sensor of size 5 cm×10 cm×15 cm (Fig.1). The first topic discussed in this paper is that the discrimination of the H3N2 and H5N1 strains of influenza viruses has been clearly achieved with the waveguide-mode sensor. We found that glycan-based detection using the waveguide sensor system analysis is very useful to distinguish between H3N2 and H5N1 viruses. The second topic concerns sensitivity comparison among the waveguide-mode sensor, immuno-chromatography, enzyme-linked immunosorbent assay (ELISA), and surface plasmon resonance (SPR). The highest sensitivity for H1N1 and H3N2 viruses was found in ELISA and the waveguide-mode sensor.

Keywords

chemical sensors; chromatography; diseases; microorganisms; patient diagnosis; surface plasmon resonance; ELISA; H1N1 viruses; H3N2 strain discrimination; H3N2 viruses; H5N1 strain discrimination; SPR; enzyme-linked immunosorbent assay; glycan-based detection; highly sensitive waveguide-mode sensor; immuno-chromatography; influenza virus subtyping; palmtop waveguide-mode sensor; sensor sensitivity; size 10 cm; size 15 cm; size 5 cm; surface plasmon resonance; waveguide sensor system analysis; Influenza; Optical reflection; Optical sensors; Optical surface waves; Optical waveguides; Sensitivity;

fLanguage

English

Publisher

ieee

Conference_Titel

SENSORS, 2013 IEEE

Conference_Location

Baltimore, MD

ISSN

1930-0395

Type

conf

DOI

10.1109/ICSENS.2013.6688224

Filename

6688224