Experimental and numerical investigation of electromagnetic field at different cancer cell lines

Author

Filipovic, Nenad D. ; Djukic, Tijana R. ; Radovic, Matija ; Cvetkovic, Dean ; Markovic, Stacey ; Jeremic, Branislav

Author_Institution

Fac. of Eng., Univ. of Kragujevac, Kragujevac, Serbia

fYear

2013

fDate

10-13 Nov. 2013

Firstpage

1

Lastpage

4

Abstract

There is a strong interest of investigation of Extremely Low Frequency (ELF) ElectroMagnetic (EM) fields in the clinic. In this study we investigated experimentally in-vitro and in-sillico with computer simulation influence of 50 Hz EM field at three different cancer cell lines: breast cancer MDA-MB-231 and colon cancer SW-480 and HCT-116. Computer reaction-diffusion model with the net rate of cell proliferation and effect of electromagnetic field in time was developed. The fitting procedure for estimation of the computer model parameters was implemented. Experimental and computer model data have shown good comparison. These findings can open a new avenue for better controlling the growth of cancer cells at specific frequencies without affecting normal tissues, which may have a great influence in clinical oncology.

Keywords

biological organs; cancer; cellular biophysics; numerical analysis; reaction-diffusion systems; tumours; breast cancer MDA-MB-231; cancer cell lines; cell proliferation; clinical oncology; colon cancer HCT-116; colon cancer SW-480; computer model parameters; computer reaction-diffusion model; computer simulation; extremely low frequency electromagnetic fields; frequency 50 Hz; Cancer; Computational modeling; Computers; Electric fields; Mathematical model; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Bioengineering (BIBE), 2013 IEEE 13th International Conference on

Conference_Location

Chania

Type

conf

DOI

10.1109/BIBE.2013.6701574

Filename

6701574