• DocumentCode
    667242
  • Title

    Studying the correlation between the extracellular environment and the diffusion processes in tumor growth

  • Author

    Ampatzoglou, Pantelis ; Hadjinicolaou, Maria

  • Author_Institution
    Sch. of Sci. & Technol., Hellenic Open Univ., Patras, Greece
  • fYear
    2013
  • fDate
    10-13 Nov. 2013
  • Firstpage
    1
  • Lastpage
    4
  • Abstract
    The tumor behavior is understood as a complex dynamical system encountering many different scales. Following the principles of Jiang et.al, we also employ a multiscale model, where the environment of a tumor, at the extracellular level is described by reaction diffusion, while at the cellular level an agent based model is applied. We further extend this model by employing a health function, which describes at every time step the health state of any tumor cell. This health function takes into account the biological and biochemical micro environment. A stochastic function is applied to model the mitosis process of proliferating tumor cells.
  • Keywords
    biochemistry; biodiffusion; cancer; cellular biophysics; chemical reactions; stochastic processes; tumours; agent based model; biochemical microenvironment; cellular level; complex dynamical system; diffusion processes; extracellular environment; extracellular level; health function; health state; mitosis process; multiscale model; reaction diffusion; stochastic function; tumor cell proliferation; tumor growth; Biological system modeling; Cancer; Computational modeling; Extracellular; Mathematical model; Numerical models; Tumors;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics and Bioengineering (BIBE), 2013 IEEE 13th International Conference on
  • Conference_Location
    Chania
  • Type

    conf

  • DOI
    10.1109/BIBE.2013.6701580
  • Filename
    6701580