Designing polymer-based immunosensing platforms for cancer biomarker detection

Author

Florea, Adrian ; Tertis, Mihaela ; Sandulescu, Robert ; Cristea, Cecilia ; Cristea, Alexandra

Author_Institution

Dept. of Anal. Chem., Iuliu Hatieganu Univ. of Med. & Pharmacy, Cluj-Napoca, Romania

fYear

2013

fDate

21-23 Nov. 2013

Firstpage

1

Lastpage

4

Abstract

The detection of multiple cancer biomarkers in human serum plays an important role for early cancer detection and represents a challenge to the development of biosensing devices. Mucines are glycoproteins, expressed in physiological conditions on the surface of epithelial tissues with role in lubrication. Several studies showed the implication of mucins (e.g. MUC1, MUC4) in the pathogenesis of ovarian cancer. This paper reviews the preliminary results of a few approaches performed in our laboratory for the design of immunosensors for mucines tumor markers detection using various immobilization platforms. Different strategies have been employed using magnetic nanobeads and conducting polymer/multiwall carbon nanotube composite films for the immobilization of the capturing antigen.

Keywords

biomagnetism; biosensors; cancer; carbon nanotubes; conducting polymers; electrochemical sensors; gynaecology; magnetic particles; nanocomposites; nanomedicine; nanoparticles; nanosensors; patient diagnosis; proteins; tumours; MUC1; MUC4; biosensing devices; capturing antigen immobilization; conducting polymer; early cancer detection; epithelial tissue surface; glycoprotein; human serum; immobilization platform; immunosensor design; lubrication; magnetic nanobeads; mucine tumor marker detection; multiple cancer biomarker detection; multiwall carbon nanotube composite films; ovarian cancer pathogenesis; physiological condition; polymer-based immunosensing platforms; Cancer; Immune system; Multiplexing; Performance evaluation; Polymers; Suspensions; Tumors; carbon nanotubes; conducting polymers; electrochemical immunosensor; tumor marker;

fLanguage

English

Publisher

ieee

Conference_Titel

E-Health and Bioengineering Conference (EHB), 2013

Conference_Location

Iasi

Print_ISBN

978-1-4799-2372-4

Type

conf

DOI

10.1109/EHB.2013.6707247

Filename

6707247