T-wave alternans predicts ICD discharge in MADIT II patients with elevated resting heart rate

Author

Monasterio, Violeta ; Martinez, Juan Pablo ; McNitt, Scott ; Laguna, P. ; Moss, Arthur J. ; Zareba, Wojciech ; Couderc, Jean-Philippe

Author_Institution

CIBER de Bioing., Biomater. y Nanomed. (CIBER-BBN), Zaragoza, Spain

fYear

2013

fDate

22-25 Sept. 2013

Firstpage

603

Lastpage

606

Abstract

The identification of MADIT II patients who might benefit the most from implantable cardioverter defibrillator (ICD) therapy remains a clinical challenge. In this work we measure T-wave alternans (TWA) using the multilead Laplacian likelihood ratio method (mLLR) in MADIT II patients, and we evaluate its ability to predict ventricular tachycardia or ventricular fibrillation events requiring an ICD shock and to predict sudden cardiac death (SCD). Our results indicate that the average TWA measured between 80 and 90 beats/min in resting ECGs is associated with future ICD therapy in MADIT II patients with elevated resting heart rate.

Keywords

Laplace equations; defibrillators; diseases; electrocardiography; prosthetics; statistical analysis; ICD discharge prediction; ICD shock; ICD therapy; MADIT II patients; SCD prediction; T-wave alternans measurement; average TWA measurement; implantable cardioverter defibrillator; mLLR method; multilead Laplacian likelihood ratio method; resting ECGs; resting heart rate elevation; sudden cardiac death prediction; ventricular fibrillation events prediction; ventricular tachycardia prediction; Abstracts; Diabetes; Electric shock; Estimation; Medical treatment;

fLanguage

English

Publisher

ieee

Conference_Titel

Computing in Cardiology Conference (CinC), 2013

Conference_Location

Zaragoza

ISSN

2325-8861

Print_ISBN

978-1-4799-0884-4

Type

conf

Filename

6713449