Study on the Thermal Characteristics of Fe3O4 Nanoparticles and Gelatin Compound for Magnetic Fluid Hyperthermia in Radiofrequency Magnetic Field

Hyperthermia is the therapy heating of certain organs or tissues to temperature 41 °C~46 °C for cancer treatment. Magnetic fluid hyperthermia, based on magnetic inductive heating (MIH) and proposed using magnetic particles as the heat mediator, is one potential treatment with great advantages and has attracted much attention in recent years. Among various kinds of magnetic materials, ferric oxide nanoparticles, such as Fe₃O₄, are widely used because of their excellent biocompatibility and easy preparation method. Considering that the working mechanism and heating properties are not fully understood, this paper studied the thermal characteristics of Fe₃O₄ nanoparticles mixed with gelatin under a radiofrequency magnetic field. After analyzing thermal physics and electromagnetic property, the relationship between heating power and parameters, including particle concentration, magnetic field intensity, and field frequency, was found in accordance with the power loss formula of a ferromagnet in a alternating magnetic field.