Optimizing nanoparticle selection and drive field properties for simultaneous MPI and hyperthermia

This paper investigates the properties of superparamagnetic iron oxide (SPIO) nanoparticles for simultaneous MPI imaging and hyperthermia therapy. For that purpose, FeraSpin SPIO nanoparticles of varying sizes (FeraSpin XS to FeraSpin XL, with hydrodynamic diameters ranging between 10 nm to 70 nm) with different concentrations (~ μM to mM) are utilized to investigate their MPI and heating efficiencies (i.e., specific absorption rate - SAR) as a function of applied magnetic field. Once the setup is fully functional, our results will provide a proof-of-concept for a potential application of MPI: simultaneous hyperthermia and imaging.