Design and construction of a high sensitivity self-shielded relaxometer

Author

Hensley, Daniel ; Bauer, Lisa ; Goodwill, Patrick ; Tay, Zhi Wei ; Griswold, Mark ; Conolly, Steven

Author_Institution

Dept. of Bioeng., Univ. of California, Berkeley, Berkeley, CA, USA

fYear

2015

fDate

26-28 March 2015

Firstpage

1

Lastpage

1

Abstract

An MPI spectrometer [1-3] measures the harmonics generated when a nonlinear SPIO is excited by a sinusoidal field. The harmonic peak spectrum allows for comparing SPIOs spatial resolution, since the harmonics are related to the modulation transfer function of the MPI imaging PSF [4-5]. It is also powerful to directly measure the point-spread function (PSF) by using the x-space MPI image reconstruction method [5-6], which has been shown to be equivalent to System Matrix reconstruction [7]. Here we describe a new design for an x-space relaxometer to increase sensitivity.

Keywords

biomagnetism; biomedical equipment; image reconstruction; iron compounds; magnetic particles; medical image processing; nanomagnetics; nanomedicine; optical transfer function; superparamagnetism; Fe₂O₃; MPI imaging; MPI spectrometer; SPIOs spatial resolution; generated harmonics; harmonic peak spectrum; high sensitivity self-shielded relaxometer; modulation transfer function; nonlinear SPIO; point-spread function; sinusoidal field; system matrix reconstruction; x-space MPI image reconstruction; x-space relaxometer; Filtering theory; Harmonic analysis; Imaging; Magnetic particles; Pollution measurement; Power harmonic filters; Sensitivity;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetic Particle Imaging (IWMPI), 2015 5th International Workshop on

Conference_Location

Istanbul

Print_ISBN

978-1-4799-7269-2

Type

conf

DOI

10.1109/IWMPI.2015.7107087

Filename

7107087