Nanostructured microsphere coated with living cells and tethered with low-stiffness wire: A possible solution to brain tissue reactions

The long term stability of the interface between neural tissue and implanted microelectrodes is very important both for research and clinical purposes. To address this challenge we developed a probe composed by an ultrathin and ultra-flexible wire as tether and a low- impedance gold sphere microelectrode as recording/stimulation site. We further improved the microsphere performance using PEDOT-CNT composite coating and we mimic the biological composition of the host tissue by coating the probe with fibroblast cells.