Analysis of a baroreflex model for the study of the chronotropic response to vagal nerve stimulation

Author

Ojeda, David ; Le Rolle, Virginie ; Rossel, Olivier ; Karam, Nicole ; Hagege, Albert ; Bonnet, Jean-Luc ; Mabo, Philippe ; Carrault, Guy ; Hernandez, Alfredo I.

Author_Institution

INSERM U1099, Rennes, France

fYear

2015

fDate

22-24 April 2015

Firstpage

541

Lastpage

544

Abstract

This paper describes the integration of computational models of the cardiovascular system, the cardiac electrical activity and the baroreceptor reflex of the autonomic nervous system, with a model representing vagal nerve stimulation (VNS). Sensitivity analyses are performed in order to find the model parameters that produce significant effects on heart rate (chronotropic effect). The most significant parameters are adjusted in order to reproduce real data acquired from sheep suffering from heart failure, during VNS periods. Results show the potential of the model to generate realistic chronotropic responses to VNS.

Keywords

bioelectric phenomena; cardiovascular system; haemodynamics; medical disorders; neurophysiology; VNS periods; autonomic nervous system; baroreflex model analysis; cardiac electrical activity; cardiovascular system; chronotropic effect; chronotropic response; chronotropic responses; computational models; heart failure; heart rate effects; model parameters; vagal nerve stimulation; Analytical models; Automata; Computational modeling; Heart rate; Mathematical model; Sensitivity analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference on

Conference_Location

Montpellier

Type

conf

DOI

10.1109/NER.2015.7146679

Filename

7146679