Biological immunoassay utilizing magnetoresistive sensor and magnetic-field-controlled binding between magnetic markers and targets

Author

Noguchi, K. ; Sakakibara, T. ; Yoshida, T. ; Enpuku, K.

Author_Institution

Kyushu Univ., Fukuoka, Japan

fYear

2015

fDate

11-15 May 2015

Firstpage

1

Lastpage

1

Abstract

This research presents the development of a magnetic immunoassay technique using magnetic markers and magnetoresistive sensor for used in the liquid phase detection of biological targets. In this method, bound and free markers can be magnetically distinguished by using Brownian relaxation of magnetic markers, eliminating time consuming washing process for marker separation. Biotin molecules as targets and streptavidin-conjugated magnetic markers were used for detection.

Keywords

Brownian motion; biological techniques; biomagnetism; biosensors; magnetic sensors; magnetoresistive devices; molecular biophysics; proteins; Brownian relaxation; biological immunoassay; biological targets; biotin molecules; liquid phase detection; magnetic immunoassay technique; magnetic-field-controlled binding; magnetoresistive sensor; streptavidin-conjugated magnetic markers; Immune system; Magnetic liquids; Magnetic moments; Magnetic separation; Nanoparticles; Noise;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetics Conference (INTERMAG), 2015 IEEE

Conference_Location

Beijing

Print_ISBN

978-1-4799-7321-7

Type

conf

DOI

10.1109/INTMAG.2015.7157194

Filename

7157194