Title :
A compact NIR fluorescence imaging system with goggle display for intraoperative guidance
Author :
Shengkui Gao ; Mondal, Suman ; Nan Zhu ; Rongguang Liang ; Achilefu, Samuel ; Gruev, Viktor
Author_Institution :
Dept. of Comput. Sci. & Eng., Washington Univ. in St. Louis, St. Louis, MO, USA
Abstract :
Near infra-red (NIR) fluorescence imaging offers high sensitivity and specificity for cancer detection and tumor margin localization. In this paper, a compact and wearable NIR fluorescence imaging system (FIS) for image guided surgery is presented. The proposed FIS captures 27 frames per second of both NIR and visible spectrum data, allowing for minimum detection of 10nM of ICG concentration. The design tradeoffs of the complete system are carefully analyzed. The performance of the proposed FIS is evaluated under both sensitivity test and experimental mouse study. The imaging system is currently used in clinical trials for imaging sentinel lymph nodes in breast cancer and melanoma patients.
Keywords :
biological organs; biomedical optical imaging; cancer; eye protection; fluorescence; infrared spectra; surgery; visible spectra; FIS captures; ICG concentration; NIR spectrum data; breast cancer; cancer detection; compact NIR fluorescence imaging system; goggle display; image guided surgery; intraoperative guidance; melanoma patients; near infrared fluorescence imaging; sensitivity test; sentinel lymph nodes; tumor margin localization; visible spectrum data; wearable NIR fluorescence imaging system; CMOS integrated circuits; Fluorescence; Image color analysis; Imaging; Light sources; Surgery; CMOS imaging sensor; NIR fluorescence imaging; image guided surgery; sensor system; wearable device;
Conference_Titel :
Circuits and Systems (ISCAS), 2015 IEEE International Symposium on
Conference_Location :
Lisbon
DOI :
10.1109/ISCAS.2015.7168960
