A comprehensive human chromosome 21 database

The article presents a new, comprehensive, user-friendly chromosome 21 database driven by a built-in protein interaction prediction tool based on Markov random field (MRF) and GeneQuest, a novel easy-to-use user interface. The database contains a wide range of data including both in-house generated data (i.e., chromosome 21 orthologs) and data collected from other existing chromosome 21 databases (i.e., protein interactions, pathways, etc.). This article describes the underlying overall database design and data preparation, explains the underlying process of built-in protein-protein interaction prediction tool based on MRF including experimental results, presents details of the GeneQuest facilities, and illustrates the results and typical uses of the database