Increased throughput for process chromatography using constrained deconvolution

Signal restoration using Jansson´s method of constrained deconvolution was investigated and tested to deconvolve and thereby resolve severely overlapped gas chromatographic peaks. The results of this technique were compared to those obtained with an instrument that uses a longer column that already produces fully resolved peaks. Jannson´s deconvolution method enabled significant resolution improvement at a minimal cost in computational time. Thus, for a given amount of peak resolution, this technique increased the instrument´s throughput by 10 times. Test results show that Jansson´s method provides similar measurement accuracies and variances as those obtained on an instrument using a longer column