Title :
A Deformable Registration Method for Automated Morphometry of MRI Brain Images in Neuropsychiatric Research
Author :
Schwarz, Daniel ; Kasparek, Tomas ; Provaznik, Ivo ; Jarkovsky, Jiri
Author_Institution :
Inst. of Biostat. & Analyses, Masaryk Univ., Brno
fDate :
4/1/2007 12:00:00 AM
Abstract :
Image registration methods play a crucial role in computational neuroanatomy. This paper mainly contributes to the field of image registration with the use of nonlinear spatial transformations. Particularly, problems connected to matching magnetic resonance imaging (MRI) brain image data obtained from various subjects and with various imaging conditions are solved here. Registration is driven by local forces derived from multimodal point similarity measures which are estimated with the use of joint intensity histogram and tissue probability maps. A spatial deformation model imitating principles of continuum mechanics is used. Five similarity measures are tested in an experiment with image data obtained from the Simulated Brain Database and a quantitative evaluation of the algorithm is presented. Results of application of the method in automated spatial detection of anatomical abnormalities in first-episode schizophrenia are presented
Keywords :
biomechanics; biomedical MRI; brain; continuum mechanics; deformation; diseases; image matching; image registration; medical image processing; probability; MRI brain images; Simulated Brain Database; automated morphometry; computational neuroanatomy; continuum mechanics; deformable registration; first-episode schizophrenia; image matching; image registration; joint intensity histogram; multimodal point similarity; neuropsychiatry; nonlinear spatial transformations; spatial deformation model; tissue probability maps; Brain modeling; Deformable models; Force measurement; Histograms; Image databases; Image registration; Magnetic field measurement; Magnetic resonance imaging; Spatial databases; Testing; Computational neuroanatomy; deformable registration; first-episode schizophrenia; magnetic resonance imaging; Algorithms; Artificial Intelligence; Brain; Computer Simulation; Elasticity; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Models, Neurological; Neuroanatomy; Neurology; Pattern Recognition, Automated; Psychiatry; Reproducibility of Results; Sensitivity and Specificity; Subtraction Technique;
Journal_Title :
Medical Imaging, IEEE Transactions on
DOI :
10.1109/TMI.2007.892512
