A Novel Zero-Drift Detection Method for Highly Sensitive GMR Biochips

Author

Han, S.-J. ; Xu, L. ; Wilson, R.J. ; Wang, S.X.

Author_Institution

Dept. of Mater. Sci. & Eng., Stanford Univ.

Volume

42

Issue

10

fYear

2006

Firstpage

3560

Lastpage

3562

Abstract

In this paper, we present a novel drift compensation mechanism for highly sensitive biodetection based on giant magnetoresistive (GMR) sensors and magnetic nanoparticles. Micromagnetic simulations showed the quantitative detection ability of this new method. The proposed detection scheme uses both ac current sources and ac magnetic fields along with two dc bias states. Experiments were carried out to detect Miltenyi Biotec (MACS) magnetic nanoparticles on the spin-valve sensor (0.2 mumtimes4 mum). The experimental results show that sub-microvolt drifts can be achieved by this dual bias-double modulation (DBDM) method

Keywords

biosensors; giant magnetoresistance; magnetic particles; magnetic sensors; nanoparticles; spin valves; GMR biochips; ac current sources; ac magnetic fields; drift compensation; giant magnetoresistive sensors; miltenyi biotec magnetic nanoparticles; spin-valve sensor; zero-drift detection; Biosensors; Electromagnetic interference; Giant magnetoresistance; Immune system; Magnetic field measurement; Magnetic sensors; Magnetization; Micromagnetics; Nanoparticles; Temperature sensors; Biosensor; micromagnetic simulation; spin-valve; temperature drift cancellation;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2006.879615

Filename

1704692