Nonlinear filtering for the estimation of glycated hemoglobin in the presence of fetal hemoglobin using microcolumn ion-exchange chromatography

Author

Yoke Lin Tan

Author_Institution

Sch. of Electr. & Electron. Eng., Nanyang Technol. Univ., Singapore

Volume

43

Issue

5

fYear

1996

fDate

5/1/1996 12:00:00 AM

Firstpage

545

Lastpage

547

Abstract

An improved method based on nonlinear least-squares to estimate the percentage concentration of glycated hemoglobin levels HbA1ab, HbA1c, HbF, and other Hb variants is presented. If the existing method is enhanced with the improved method, the use of microcolumn ion-exchange chromatography for estimating glycated hemoglobin levels even for patients with elevated fetal hemoglobin (HbF) would provide a more realistic estimate.

Keywords

biomedical measurement; blood; chemical variables measurement; chromatography; filtering theory; ion exchange; least squares approximations; patient diagnosis; proteins; Hb variants; HbA1ab; HbA1c; HbF; diabetic patients; elevated fetal hemoglobin; fetal hemoglobin; glycated hemoglobin estimation; long-term glycaemic control; microcolumn ion-exchange chromatography; nonlinear filtering; nonlinear least-squares; percentage concentration; Blood; Costs; Curve fitting; Diabetes; Filtering; Monitoring; Newton method; Performance analysis; Postal services; Resins; Chromatography, Ion Exchange; Fetal Hemoglobin; Filtration; Hemoglobin A, Glycosylated; Humans; Least-Squares Analysis; Nonlinear Dynamics;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.488801

Filename

488801