CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance

Author

Sun, Nan ; Liu, Yong ; Lee, Hakho ; Weissleder, Ralph ; Ham, Donhee

Author_Institution

Sch. of Eng. & Appl. Sci., Harvard Univ., Cambridge, MA

Volume

44

Issue

5

fYear

2009

fDate

5/1/2009 12:00:00 AM

Firstpage

1629

Lastpage

1643

Abstract

We report on a CMOS RF transceiver designed for detection of biological objects such as cancer marker proteins. Its main function is to manipulate and monitor RF dynamics of protons in water via nuclear magnetic resonance (NMR). Target objects alter the proton dynamics, which is the basis for our biosensing. The RF transceiver has a measured receiver noise figure of 0.7 dB. This high sensitivity enabled construction of an entire NMR system around the RF transceiver in a 2-kg portable platform, which is 60 times lighter, 40 times smaller, yet 60 times more mass sensitive than a state-of-the-art commercial benchtop system. Sensing 20 fmol and 1.4 ng of avidin (protein) in a 5 muL sample volume, our system represents a circuit designer´s approach to pursue low-cost diagnostics in a portable platform.

Keywords

CMOS integrated circuits; biomedical NMR; biomedical electronics; biosensors; cancer; integrated circuit design; patient diagnosis; portable instruments; proteins; transceivers; tumours; CMOS RF biosensor design; RF proton dynamics; RF transceiver; avidin; benchtop system; biological object detection; cancer marker proteins; low-cost diagnostics; nuclear magnetic resonance; portable system; receiver noise figure; Biosensors; Cancer detection; Manipulator dynamics; Monitoring; Nuclear magnetic resonance; Object detection; Proteins; Protons; Radio frequency; Transceivers; Biosensor; CMOS integrated circuit; RF transceiver; low noise amplifier; nuclear magnetic resonance;

fLanguage

English

Journal_Title

Solid-State Circuits, IEEE Journal of

Publisher

ieee

ISSN

0018-9200

Type

jour

DOI

10.1109/JSSC.2009.2017007

Filename

4907323