A noninvasive LSO-APD blood radioactivity monitor for PET imaging studies

Author

Shokouhi, Sepideh ; Stoll, Sean P. ; Villanueva, Azael ; Vaska, Paul ; Schlyer, David J. ; Woody, Craig L. ; Yu, Bo ; O´Connor, Paul ; Pratte, Jean-Francois ; Radeka, Veljko ; Volkow, Nora ; Fowler, Joanna S.

Author_Institution

Dept. of Biomed. Eng., State Univ. of New York, Stony Brook, NY, USA

Volume

50

Issue

5

fYear

2003

Firstpage

1457

Lastpage

1461

Abstract

A study has been carried out to investigate the possibility of using a pair of LSO + APD detector arrays to obtain a noninvasive measurement of the arterial input function for use in PET. The main focus of this study was to determine the spatial resolution and sensitivity required to obtain a high quality image that would permit a precise determination of the region of interest around the wrist artery. From these data a quantitative arterial input function that has minimal interference from the tissue and vein background can be obtained. The detector arrays were operated in coincidence counting mode to obtain planar images of various phantoms to demonstrate the feasibility of the concept.

Keywords

avalanche photodiodes; blood; coincidence techniques; phantoms; positron emission tomography; radioactivity measuring apparatus; solid scintillation detectors; PET imaging studies; arterial input function; coincidence counting mode; noninvasive LSO-APD blood radioactivity monitor; phantoms; planar images; positron emission tomography; wrist artery; Arteries; Blood; Detectors; Focusing; Monitoring; Noninvasive treatment; Positron emission tomography; Sensor arrays; Spatial resolution; Wrist;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/TNS.2003.817284

Filename

1236949