Title :
Stokes shift emission spectroscopy of human tissue and key biomolecules
Author :
Alfano, R.R. ; Yang, Yuanlong
Author_Institution :
Phys. Dept., City Univ. of New York, NY, USA
Abstract :
The Stokes-shifted emission spectra were measured for various photoactive biomolecules in aqueous solution and tissue such as tryptophan, collagen, nicotinamide adenine dinucleotide, and flavin. Information is obtained on the molecular activity in the tissue. This new approach allows for the extraction of some new information not obtained from excitation and/or fluorescence spectroscopy for a single spectral scan.
Keywords :
biological techniques; biological tissues; cancer; diseases; fluorescence spectroscopy; molecular biophysics; proteins; spectral line shift; Stokes shift emission spectroscopy; absorption; aqueous solution; atherosclerosis; cancer; collagen; disease state; flavin; fluorescence; human tissue; key biomolecules; molecular activity; nicotinamide adenine dinucleotide; photoactive biomolecules; precancer; single spectral scan; tryptophan; Absorption; Amino acids; Biomedical optical imaging; Fluorescence; Humans; Molecular biophysics; Physics; Proteins; Spectroscopy; Stimulated emission;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2003.811285
