Hall Biosensor With Integrated Current Microstrips for Control of Magnetic Beads

Author

Kumagai, Yoshimichi ; Togawa, Kiyoshi ; Sakamoto, Satoshi ; Abe, Masanori ; Handa, Hiroshi ; Sandhu, Adarsh

Author_Institution

Dept. of Electr. & Electron. Eng., Tokyo Inst. of Technol.

Volume

42

Issue

12

fYear

2006

Firstpage

3893

Lastpage

3895

Abstract

Magnetic labeling of biomolecules shows potential as an alternative to fluorescence for monitoring molecular interactions associated with DNA hybridization and antibody-antigen analysis. Current carrying microstrips were integrated with micro-Hall biosensors to manipulate and collect superparamagnetic beads by field gradients generated due to direct currents passed through the strips. Magnetic beads with 2.8-mum diameters were collected over the active regions of AlGaAs/InGaAs heterostructure micro-Hall biosensors and detected in real time. The integration of current-carrying microstrips with Hall biosensors will decrease the time required for detecting biomolecular recognition processes in Hall sensor-based bioscreening platforms

Keywords

Hall effect devices; III-V semiconductors; aluminium compounds; biosensors; gallium arsenide; indium compounds; magnetoresistive devices; microsensors; 2.8 micron; AlGaAs-InGaAs; DNA hybridization; Hall biosensor; antibody-antigen analysis; integrated current microstrips; molecular interactions monitoring; supermagnetic beads; Biosensors; DC generators; DNA; Fluorescence; Labeling; Magnetic analysis; Microstrip; Molecular biophysics; Monitoring; Strips; Bioscreening; Hall effect; superparamagnetic beads;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2006.879613

Filename

4015538