Title :
A 128 × 128 CMOS biosensor array for extracellular recording of neural activity
Author :
Eversmann, Björn ; Jenkner, Martin ; Hofmann, Franz ; Paulus, Christian ; Brederlow, Ralf ; Holzapfl, Birgit ; Fromherz, Peter ; Merz, Matthias ; Brenner, Markus ; Schreiter, Matthias ; Gabl, Reinhard ; Plehnert, Kurt ; Steinhauser, Michael ; Eckstein, Ge
Author_Institution :
Corporate Res., Infineon Technol. AG, Munich, Germany
Abstract :
Sensor arrays are a key tool in the field of neuroscience for noninvasive recording of the activity of biological networks, such as dissociated neurons or neural tissue. A high-density sensor array complementary metal-oxide-semiconductor chip is presented with 16 K pixels, a frame rate of 2 kiloframes per second, and a pitch of 7.8 μm × 7.8 μm for imaging of neural activity. The related circuit and system issues as well as process aspects are discussed. A mismatch-canceling calibration circuitry with current mode signal representation is used. Results from first biological experiments are presented, which prove full functionality of the chip.
Keywords :
CMOS integrated circuits; bioelectric potentials; biomedical electrodes; biomedical electronics; biomedical transducers; biosensors; neurophysiology; CMOS biosensor array; bioelectric potentials; biomedical transducers; current mode signal representation; extracellular recording; high-density sensor array; mismatch-canceling calibration circuitry; multi-electrode array; neural activity; noninvasive recording; pixel circuit; Biological tissues; Biosensors; Calibration; Circuits and systems; Extracellular; Image sensors; Neurons; Neuroscience; Pixel; Sensor arrays;
Journal_Title :
Solid-State Circuits, IEEE Journal of
DOI :
10.1109/JSSC.2003.819174
