A new method to destruct targeted cells using magnetizable beads and pulsed magnetic force

Author

Ogiue-Ikeda, Mari ; Sato, Yuko ; Ueno, Shoogo

Author_Institution

Dept. of Biomed. Eng., Univ. of Tokyo, Japan

Volume

2

Issue

4

fYear

2003

Firstpage

262

Lastpage

265

Abstract

We investigated a new method to destruct targeted cells using magnetizable beads and pulsed magnetic force. The cells were combined with the beads by an antigen-antibody reaction (cell/bead/antibody complex), aggregated by a magnet, and stimulated by a magnetic stimulator. The viability of the aggregated and stimulated cell/bead/antibody complexes was significantly decreased, and the cells were destructed by the penetration of the beads into the cells or rupturing of the cells by the beads. These results suggest that magnetic aggregation and pulsed magnetic stimulation can effectively damage only the cells targeted by an antigen-antibody reaction.

Keywords

biological effects of fields; biomagnetism; cancer; cellular biophysics; patient treatment; antigen-antibody reaction; cancer cells; magnetic stimulator; magnetizable beads; pulsed magnetic force; targeted cell destruction; Biomedical engineering; Cancer; Coils; Iron; Magnetic fields; Magnetic forces; Magnetic materials; Magnetic stimulation; Mice; Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Radiation; Ferric Compounds; Humans; Immunomagnetic Separation; Leukemia, Myeloid; Magnetics; Microspheres; Radiation Dosage; Radiometry; Stress, Mechanical; Treatment Outcome;

fLanguage

English

Journal_Title

NanoBioscience, IEEE Transactions on

Publisher

ieee

ISSN

1536-1241

Type

jour

DOI

10.1109/TNB.2003.820276

Filename

1254530