Co-Ni-W-P Magnetic Films Electrolessly Deposited on Nitinol and the Application in Magnetically Targeted Therapy

Author

Cheng, Haibin ; Xu, Shuai ; Zou, Shengquan ; Zhang, Qingjie ; Zheng, Jianwei ; Zhao, Wenyu ; Guan, Jianguo ; Sun, Zhigang

Author_Institution

State Key Lab. of Adv. Technol. for Mater. Synthesis & Process., Wuhan Univ. of Technol.

Volume

43

Issue

6

fYear

2007

fDate

6/1/2007 12:00:00 AM

Firstpage

2433

Lastpage

2435

Abstract

Co-Ni-W-P magnetic films were electrolessly deposited on the nitinol wires. Their composition, microstructure, and magnetic properties were characterized by EDS, FESEM, and VSM. Their application in magnetically targeted therapy was investigated on animals. It was found that their composition and surface morphology can be controlled by the bath pH which can strongly influence the H_c, M_r, and BH_max. The magnetic nitinol wires with the Co-Ni-W-P films, combining with the magnetic nanoparticles containing 5-FU, were confirmed to be able to effectively inhibit the growth of tumors.

Keywords

X-ray chemical analysis; biomagnetism; cobalt alloys; crystal structure; electroless deposition; magnetic particles; magnetic thin films; nanobiotechnology; nanoparticles; nickel alloys; pH; phosphorus alloys; radiation therapy; scanning electron microscopy; surface morphology; titanium alloys; tumours; tungsten alloys; CoNiWP; EDS; FESEM; NiTi; VSM; composition; electroless deposition; magnetic films; magnetic nanoparticles; magnetic properties; magnetically targeted therapy; microstructure; nitinol wires; pH; surface morphology; tumours; Magnetic films; Magnetic materials; Magnetic properties; Materials science and technology; Medical treatment; Microstructure; Neoplasms; Substrates; Surface morphology; Wires; Co-Ni-W-P magnetic film; magnetic property; magnetically targeted therapy; microstructure;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2007.893851

Filename

4202748